Effect of yogurt on fluoride induced toxicity of plasma markers of kidney in rabbits

Abstract

Fluoride (F) is one of the major chemical substances that damage the renal tissue prevention tubular reabsorption, increasing the excretion of sodium (Na+) and chloride (cl-), and enhancing creatinine (Cr), uric acid (UA), blood urea nitrogen (BUN) and potassium (K+) level.  Results revealed that on 16^th day in groups B, D, E and G, Cr. values were significantly (P˂0.05) increased on 31^st day in group-F, Cr. value was significantly (P˂0.05) decreased, whereas, in groups-B, D, E and G, Cr. values were significantly increased (P˂0.05). On 16^th and 31^st day, in yogurt-treated groups i.e.- C and F, UA values were significantly (P˂0.05) decreased, whereas, in groups B, D, E and G, UA values were significantly (P˂0.05) increased. On 16^th and 31^st day, in groups-B, D, E and G BUN level was significantly (P˂0.05) increased. On 16^th and 31^st day in groups-B and E, Na+ level was significantly (P˂0.05) decreased. Whereas, in groups C, D, F and G, Na+ level was significantly (P˂0.05) increased. Likewise, on 16^th and 31^st day, in groups-B, D, E and G, K+ level was significantly (P˂0.05) increased. On 16^th day in groups-B and E, cl- level was significantly (P˂0.05) decreased. While, in groups- F and G cl- level was significantly (P˂0.05) increased. On 31st in groups-B & E, cl- level was significantly (P˂0.05) decreased. While, in groups-C, D, F and G, cl- levels was significantly (P˂0.05) increased. It has been concluded that increased levels of sCr, UA, BUN, K+ and reduced levels of Na+ and cl- were observed in all fluoride treated groups. Yogurt-treated groups showed decreased levels of Cr, UA, BUN and K+ and increased levels of Na+ and Cl- in experimental rabbits